Background: Professionalism and medical ethics constitute the foundation of healthcare practice. As healthcare systems become increasingly complex, medical schools are expected to produce physicians who demonstrate clinical competence, ethical decision-making abilities, empathy, accountability, and professional conduct.

Objective: To evaluate the effectiveness of professionalism and ethics education in medical schools and assess its impact on medical students' ethical awareness, professional behavior, and clinical decision-making.

Methods: A cross-sectional mixed-method study was conducted among 500 undergraduate medical students from five medical institutions. Data were collected through structured questionnaires, ethical scenario assessments, and focus group discussions. Statistical analyses included descriptive statistics, chi-square tests, and regression analysis.

Results: Among participants, 88% acknowledged the importance of professionalism and ethics education. Students exposed to structured ethics curricula demonstrated significantly higher ethical reasoning scores (81.5%) compared to those receiving traditional instruction (67.3%). Professional behavior assessments improved progressively with academic year progression. Communication skills, patient confidentiality awareness, and informed consent understanding showed notable improvements following ethics training.

Conclusion: Professionalism and ethics education significantly enhances ethical competence, professional behavior, and patient-centered care among medical students. Integration of longitudinal ethics curricula and experiential learning approaches is recommended.